Codeine and opioid metabolism
نویسندگان
چکیده
منابع مشابه
Opioid disposition in human sweat after controlled oral codeine administration.
BACKGROUND Characterization of opioid excretion in sweat is important for accurate interpretation of sweat tests in drug treatment, criminal justice, and workplace drug testing programs. METHODS Participants (n=20) received placebo, 3 low (60 mg/70 kg) or 3 high (120 mg/70 kg) codeine sulfate doses (used as a model for opioid excretion) within 1 week. Codeine and metabolites in sweat were col...
متن کاملOpioid metabolism.
Clinicians understand that individual patients differ in their response to specific opioid analgesics and that patients may require trials of several opioids before finding an agent that provides effective analgesia with acceptable tolerability. Reasons for this variability include factors that are not clearly understood, such as allelic variants that dictate the complement of opioid receptors ...
متن کاملPharmacogenetics of neonatal opioid toxicity following maternal use of codeine during breastfeeding: a case-control study.
A large number of women receive codeine for obstetric pain while breastfeeding. Following a case of fatal opioid poisoning in a breastfed neonate whose codeine prescribed mother was a CYP2D6 ultrarapid metabolizer (UM), we examined characteristics of mothers and infants with or without signs of central nervous system (CNS) depression following codeine exposure while breastfeeding in a case-cont...
متن کاملCodeine and methadone interactions
Cytochrome P450; Drug Interactions; CYP3A4; CYP2D6; Metabolites; Opioids. Introduction metabolism of codeine, fentanyl, methadone, oxycodone, and . WebMD provides information about interactions between Codeine Sulfate Oral and. Buprenorphine effects in methadone-maintained volunteers: effects at two . Methadone is a potent drug, and can interact with other drugs to have block the high of other ...
متن کاملPharmacogenetics of codeine metabolism in an urban population of children and its implications for analgesic reliability.
BACKGROUND Codeine analgesia is wholly or mostly due to its metabolism to morphine by the cytochrome P450 enzyme CYP2D6, which shows significant genetic variation in activity. The aims of this study were to investigate genotype, phenotype and morphine production from codeine in children undergoing adenotonsillectomy, and to compare analgesia from codeine or morphine combined with diclofenac. ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Current Opinion in Anaesthesiology
سال: 2017
ISSN: 0952-7907
DOI: 10.1097/aco.0000000000000455